ABSTRACT

Background: Thyroid gland stands for a part of endocrine system in a human body, and it works to manufacture, store, and secrete hormones in the blood in order to reach the cells of the body, and has many important functions in the human bodyheart and blood vessels, metabolism, pregnancy, skeletal muscles and thyroid disorders.

Thyroid gland diseases represent a global health issue. The imbalance in a regulation of thyroid hormones can instigate as well numerous disorders. Aim:This study aimed to find a direct relationship between DHVD3 and GR levels with thyroid hormones, which can lead to thyroid disorders that are directly affected by the levels of these hormones. Methods:The study was conducted between September 2018 to July 2019 in the Specialized Center for Endocrinology and Diabetes in Baghdad province / Iraq. : Serum triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and glutathione reductase (GR) and 1, 25 -Dihydroxyvitamin D3 (DHVD3) activities also, BMI, HbA1C were determined for 100 subjects, including 80 patients divided into two groups. Group I (20 hypothyroidism, 20 subclinical hypothyroidism), Group II (20 hyperthyroidism, 20 subclinical hyperthyroidism) and 20 healthy subjects as control groups.Results: showed a significant increase compared with control group in HbA1c in hypothyroidism and subclinical hypothyroidism but other student groups unchangedIt could also be observed a significant decrease in vitamin D and GR in hypothyroidism and subclinical hyperthyroidism but with a significant increase in hyperthyroidism and subclinical hypothyroidism.Conclusion:in correlation between vit D3 deficiency and thyroid dysfunction was also found with Glutathione Reductase (GR) as a result of oxidative stress which indicated these parameters effect on thyroid dysfunction.

Keywords: Hyperthyroidism, hypothyroidism, 1, 25 -Dihydroxyvitamin D3 (DHVD3) and Glutathione Reductase