ABSTRACT

Aim: To determine the H. pylori infection in patients by two diagnostic methods serology and biopsy for histology using upper gastrointestinal endoscopy. Study design: Descriptive case series Place and duration of study: Department of Gastroenterology Chandka Medical College Hospital Larkana from 1st October 2019 to 31st March 2020. Methodology: One hundred and fifty two patients having acid peptic disorder were enrolled and the history of patient was taken. Five ml sample of blood was taken for serology testing whereas three biopsies samples were taken from antrum of stomach and for histology. Results: The frequency of H pylori infection was found by histologically (73%) and serologically was (85.5%) that was significantly higher than histology. The histopathology results indicate as accurate procedures in diagnosis of H. pylori compared to ICT detection as antibodies persist in body for long period after treatment.

Conclusion: In the era, where upper GI endoscopy is widely available at an affordable cost consider before eradication .serology test alone is not sufficient for treatment of infection.

Key words: H, pylori, Histology, Serology