ABSTRACT

Background: Globally thousands of elective abdominal surgeries are being conducted under general Anaesthesia. Muscle relaxants are principally used to provide good muscle relaxation for induction and maintenance of Anaesthesia.

Aim: To compare the mean consumption of atracurium with and without administration of intra-venous magnesium sulphate in patient undergoing abdominal procedures under general anaesthesia.

Place and dates: Department of Anesthesiology, Sh. Zayed Hospital, Lahore from February 2016 to August 2016.

Methodology: This is a randomized control trial study and carried out in the Department of Anaesthesia at Shaikh Zayed Hospital, Lahore within one year. A total of hundred cases; 50 in each group and taking magnitude of atracurium consumption i.e., 340.7±81.7ug/kg/h in control group and 183.7±78.1ug/kg/h in MgSO4 group in patients undergoing abdominal surgeries under general anaesthesia. Patients were randomized by lottery method in group A (Magnesium Group). Patients were given 50mg/kg Magnesium Sulphate in slow IV infusion from Intra operatively and in group B, patients were given normal saline as placebo

Results: With magnesium sulphate, the mean consumption of atracurium was 181.24±23.04 and without magnesium sulphate, the mean consumption of atracurium was 339.54±23.68. There is a significant difference in mean consumption of atracurium with and without magnesium sulphate (p<0.000).

Conclusion: There is a significant difference in mean consumption of atracurium with and without magnesium sulphate. It is less with administration of intravenous magnesium sulphate as compared to normal saline in patients undergoing abdominal surgeries under general anaesthesia.

Key Words: Atracurium, Magnesium Sulphate, Anesthesia, Abdominal Surgeries