Aim: To determine factors influencing the outcome of status epilepticus in patients present to a tertiary care hospital

Study Design: Retrospective Cross-sectional study

Place and duration: This study was conducted in Jinnah Post Graduate Medical Centre Karachi Pakistan. From January 2019 to January 2020.

Methodology: This study carried out a retrospective review on the patients suffering from Status Epilepticus who were admitted in the hospital of Sindh, Pakistan. Patient details were used to investigate the prognostic values, including demographic, clinical and etiological factors. These factors were determined using statistical tests where a 5% significance level was utilized for these tests.

Results: A study group of 180 patients was analyzed and the mortality rate was determined to be 23 (13%). Morbidity was also analyzed and it was observed in 45 (25%) patients. It was also observed that males had significantly higher mortality rates. It was seen that CNS infections were the most common cause of epilepsy in patients suffering from Status Epilepticus (n=54). A greater morbidity rate was found for patients suffering from acute symptomatic causes of Status Epilepticus (p=0.000).

Conclusion: The key causes for mortality in patients admitted for Status Epilepticus were CNS infections, prolonged seizures and seeking late medical attention. Higher mortality rates were also associated with males and patients who had poor control of their seizures. Acute and symptomatic etiologies were also found to be a common determinant in higher morbidity rates.

Keywords: Status Epilepticus, Central nervous system infections, adults