Frequency of Dyslipidemia in patients with Psoriasis and Association with Disease Severity
Ayesha Kiran, Zahra Babar, Aqsa Naheed, Sobia Awan, Bilqees Fatima, Urooj Mirza, Farid-ur-Rehman
3430
ABSTRACT
Background: Psoriasis is a recurrent disfiguring skin disease, associated with
abnormal lipid metabolism and with high occurrence of cardiovascular complications.
This linked to the extent of disease, as it is often seen in those patients who
have larger body areas involved with psoriasis.
Objective: To estimate
frequency of dyslipidemia in psoriatic patients and to determine the frequency
of dyslipidemia in psoriatic patients based on the severity of disease.
Study Design: Cross-sectional study
Place and Duration of
Study: Department
of Dermatology, Fauji Foundation Hospital Rawalpindi from 1stMarch
2017 to 30th September 2017.
Methodology: One hundred and fifty cases were enrolled.
All cases were enrolled and 3ml of blood was collected following 12 hrs of
fasting for determination of lipid profile. Blood sample was sent to the
Hospital laboratory and reports were verified by senior pathologists. Severity
of psoriasis was determined according to PASI score.
Results: Age of
participants was between 18-60 years with mean 38.88±12.26 years and 29 (19.33%)
male and 121 (80.67%) female cases. According to severity of disease, 50 (33.3%)
cases had mild, 70 (46.7%) had moderate and 30(20%) cases had severe
Psoriasis. The mean cholesterol,
triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL)
was 12.91 ± 2.17, 8.93 ± 2.90, 5.0 ± 2.28 and 1.98 ± 0.31 respectively. There were
100(66.7%) cases who had dyslipidemia and 50(33.3%) had normal lipid profile.
Conclusion: Frequency of dyslipidemia is very high and is associated
with severity of psoriasis.
Keywords: Psoriasis, Dyslipidemia, Lipid profile and Cardiovascular
disease.