Objective: To determine the ST resolution in patients given streptokinase along with guideline medical therapy

Methodology: This descriptive cross sectional study was carried out in department of Cardiology DHQTH KDA Kohat on 109 patients after obtaining informed consent from the patients. Patients were given guideline directed medical therapy & streptokinase for ST elevation MI. The ST-segment elevation resolution was calculated after 90 minutes of treatment with streptokinase, and stratified as complete ST segment resolution (> 70% ST-resolution), partial resolution (30-70% ST-resolution), or failed resolution (< 30% ST-resolution).

Results: Out of 109 patients, 33 were females & 76 were male patients. Mean age of the population was 57±11.64 (95% CI). Time from onset of chest pain to administration of thrombolytic & guideline directed medical therapy was within 6 hours for 95 patients (87.5%).Out of 109, 9(8%) patients had minor gum bleeding.

Conclusion: Administration of streptokinase is cost effective therapy for STEMI patients & give good resolution of ST segment on ECG.

Key Words: Myocardial infarction, ST resolution