Aim: To discover and relate the role of sleep with pain perception in patients undergoing endodontic therapy.

Study design: The study was quantitative correlational design in nature.

Place and duration of study: Department of Operative Dentistry, Dental section Islam Dental College, Sialkot. Duration of study was two years 2019-2020

Methods: Five hundred patients were included in the study, which were scheduled for endodontic therapy.

Results: Five hundred patients were included in the study. The correlation between sleep and pain during endodontic therapy was -.039 which was found non-significant. 250 cases have mild pain (50%), 158 cases (31.6%) have moderate pain, 92 cases (18.4%) have severe pain. Sleep deprived cases in the study were 264(52.8%), while cases who were practicing good sleeping habits were 236 (47.25%).

Conclusion: There exists a statistically significant relationship between perception of pain during endodontic therapy and sleep. In order to improve the outcome of endodontic therapy dental professionals should educate their patients on the importance of good sleep hygiene along with dental hygiene.

Keywords: Sleep, pain, endodontic therapy.