ABSTRACT

Objective: To determine the frequency of cagA and babA of helicobacter pylori isolated from gastric atrophic patients. Study Design: Descriptive/analytical study

Place & Duration of Study: Department of Medicines, Chandka Medical College Hospital, Larkana and Khairpur Medical College, Khairpur Mirs from 1st April 2020 to 30th September 2020. Methods: One hundred and twenty patients of both genders were presented in this study. Patients were aged between 20-80 years of age. Patients detailed demographics age, sex and body mass index were recorded after taking informed written consent. All patients of gastroduodenal disorders were undergone for isolation of bacteria by using standard techniques. Results: Fifty (41.7%) patients were males and 70 (58.3%) patients were females. Mean age of the patients were 41.96±16 years with mean BMI 25.24±4.8 kg/m2. Helicobacter pylori was isolated in 30 (25%) patients in which 13 patients had atrophic gastritis, 9 patients had gastric ulcer and 8 patients had acute gastritis. Frequency of cagA gene was 16 (53.4%) and babA was 10 (33.4%) in H. pylori isolated patients. Conclusion: Different cagA positive H. pylori can be retrieved from gastric atrophy patients. Keyword: Gastric atrophy, Gastric cancer, cagA, babA, Helicobacter pylori