Objective: To determine the role of Medical Therapy & Surgery in enlarged benign prostatic Hyperplasia in early stage.

Study Design: Prospective observational study:

Setting: This study was conducted at Liaquat University of medical and health sciences Jamshoro

Duration: and Duration: Two years study from February 2018 to January 2020.

Patients and Methods: The Prospective observational study was carried out in the department of surgery surgical unit 1 ward 2 at Liaquat University of medical & health sciences Jamshoro. All the patients having enlarged benign prostate hyperplasia were included. Included patients underwent medical history and complete clinical examination including ultrasound of abdomens and prostate, Urine DR, Urine Culture and other required laboratory investigations. Patients underwent both medical surgical treatments. All the patients were followed for one year and their outcomes were noted. All the data was recorded via self-made proforma. Data analysis was done by using SPSS version 20.

Result: Total 50 patients were incorporated; their mean age was 58.34 ± 10.55 years. Mean duration symptoms was 8.36±2.21 months. Out of all 22 patients were presented with irrigative symptoms, 18 patients had irrigative and obstructive symptoms and 10 patients had obstructive symptoms. Majority of the patients 22 out of all had IPSS scoring of 20-35. Both medical and surgical treatment showed significant results. However Alpha adrenergic blocking plus TURP combine therapy was found to more effective treatment option for severely enlarged benign prostate hyperplasia to early decreases the symptoms.

Conclusion: It was concluded that Alpha Adrenergic Blocking plus 5 alpha Reductase inhibitor combine treatment was more effective in patients having mild to moderate enlarged benign prostate hyperplasia, while Alpha adrenergic blocking plus TURP was the effective treatment option for patients having severe benign Prostatic Hyperplasia to decrease the symptoms immediately.