Frequency of Abnormal Placental Histopathology and their Association with Adverse Perinatal Outcomes
Saira Ghafoor, Nazish Ali, Zafar Haleem Baloch, Syedafariha Hussain, Aliya Waheed, Fehmida
2067
Abstract
Objective:
To determine the frequency and pattern of
abnormal placental histopathology and its impact on adverse fetal outcomes.
Study
Design: Cross-sectional/Observational
Place
and Duration: This study was conducted at department of Obstetrics and Gynaecology, Jinnah Medical
and Dental College Hospital Korangi, Karachi for duration of six months from 1stJune
2019 to 30thNovember 2019.
Methodology:
One hundred and fifty five women with normal
or C-section deliveries were enrolled. After taking informed written consent,
detailed demographics including age, gestational age, body mass index, mode of
delivery and co-morbidities were recorded. Placenta of each patient was
examined macroscopically and sent to laboratory for histopathological
examination. Frequency of abnormal placenta was recorded. Association between
abnormal placenta and poor neonatal outcomes were examined. Data was analyzed
by SPSS 27.0.
Results:
Mean age of patients was 28.75±5.34 years.
Mean gestational age was 38.24±2.16 weeks. Abnormal placenta was found in 45 (29.03%)
patients while 70.97% had normal placenta on histopathology. Out of 45 abnormal
placenta, vessel wall thickness was found in 31 (68.89%), infarction found in 8
(17.77%), chorioangiosis found in 4 (8.89%), and villitis in 2 (6.67 %). A
significant association was observed between abnormal placenta and adverse
fetal outcomes with p-value <0.05.
Conclusion:
Abnormal placental histopathology was found
in 29.03% and significantly associated with adverse fetal outcomes.
Keywords: Placental Histopathology, Neonatal Outcomes, Neonatal death, Low-birth
weight, NICU Admission, Apgar Score.