Abstract

Objective: The aim of this study is to determine the relationship between serum resistin level in patients of hypertensive coronary artery disease and patients with only coronary artery disease.

Study Design: Comparative

Place and Duration: Conducted in Sahiwal Medical College and DHQ hospital Sahiwal for duration of six months from 15th November 2019 to 15th April 2020.

Methods: Total 180 patients of both genders were included in this study. Patients’ detailed demographics including age, sex and body mass were recorded after taking written consent. Patients were divided into two equal groups I and II. Group I had hypertensive patients and group II had coronary artery disease patients. Serum resistin level was measured between both groups. Complete data was analyzed by SPSS 24.0 version.

Results: Equal number of males and females were included in both groups. Mean age of the patients in group I was 54.83 ± 12.09 years with mean BMI 27.14 ± 7.18 kg/m2, while mean age in group II was 53.38 ± 12.90 years with BMI 26.41 ± 9.18 kg/m2. Serum resistin in hypertension was high as compared to coronary artery disease.The values of serum resistin, triglycerides and low-density lipoproteins were found progressively high in group I as compared to group II.

Conclusion: Serum levels of resistin, triglycerides and LDL are significantly raised while serum HDL levels are significantly lowered in patients of hypertension and coronary artery disease.

Keywords: Coronary artery disease, Hypertension, Resistin, Lipid profile