Abstract

Objective: To compare the efficacy of propofol 1% and propofol 0.5% admixture with thiopentone 1% in terms of Hemodynamic stability and ease of insertion of LMA among paediatric patients undergoing elective general surgical procedures.

Patients and Methods: It was a randomized controlled trial conducted at Pediatric Surgery Department, Mayo Hospital Lahore, for a period of 6 months from 02-06-2019 to 19-12-2019. A total of 104 patients aged 3-12 years of either gender undergoing elective general surgery were included and divided in two equal groups. 10 ml of propofol 1% was given to Group A and for Group B, propofol 1%, thiopentone 2% was mixed in a 1:1 ratio. Ease of insertion of LMA was scored according to LMA Insertion Score. The hemodynamics (pulse and blood pressure) was monitored after 1 minute and after 3 minutes.

Results: The mean age of patients in group A was 7.38 ± 1.95 years and in group B was 7.44 ± 2.05 years. Out of these 104 patients, 60 (57.69%) were male and 44 (42.31%) were females. Ease of insertion was found in 37 (71.15%) group A (propofol 1%) patients and in 46 (88.46%) group B (propofol 0.5% admixture with thiopentone 1%) patients (p-value = 0.028). Hemodynamic stability was found in 27 (51.92%) patients of group A and in 41 (78.86%) patients of group B (p-value = 0.004).

Conclusion: The efficacy of propofol 0.5% admixture with thiopentone 1% is better in terms of hemodynamic stability and ease of insertion of LMA among paediatric patients undergoing elective general surgical procedures as compared to propofol 1%.