Abstract

Objective: The objective of the study was to determine the frequency of cardiac valve calcification in ESRD patients who are on maintenance hemodialysis.

Study design: Descriptive Cross-sectional study

Place and Duration of Study: Department of Nephrology (Dialysis Unit), Liaquat University of Medical & Health Sciences, Jamshoro from 1st August 2019 to 31st January 2020.

Methodology: One hundred and twenty patients with end stage renal disease on maintenance hemodialysis having age 18 to 70 yearsof either gender were included. Investigations was advised for Serum parathyroid hormone, C-reactive protein, calcium and phosphorus. Echocardiography was performed for the evaluation of cardiac valve calcification.

Results: The average age of the patients was 50.67±13.70 years. The cardiac valve calcification was found to be 62 (51.7%). Of 62 patients with cardiac valve calcification, mitral valve calcification was found to be 44 (71%), aortic valve 31 (50%), and mitral annulus 50 (80.6%) respectively. A significant association of cardiac valve calcification was observed with age (P<0.002), serum CRP level (P<0.001), serum phosphorus level (P<0.001) and hypertension (P<0.002).

Conclusion: The cardiac valve calcification in majority of the patients and mitral annulus was found to be higher 80% followed by mitral valve and aortic valve calcification.

Keywords: Cardiac valve calcification, End stage renal disease (ESRD), Mitral annulus, Mitral valve calcification, Aortic valve