Abstract

Objective: To assess the effectiveness of tranexamic acid for prevention of postoperative seroma formation in patients undergoing ventral hernioplasty. Study Design: Cross-sectional study

Place and Duration of Study: Department of Surgery, Khairpur Medical College Khairpur Mir’s from 1st January 2020 to 30th June 2020.

Methodology: Ninety patients registered for the comprehensive demographic age, sex and body mass index. The patients were 20 to 60 years of age. They were divided in two equal groups; Group A patients received tranexamic acid 1gm postoperatively while group B did not received tranexamic acid. Drain output at 1st and 5th postoperative day was measured. Duration of drain was recorded and compare between both groups.

Results: Group A had 13 (28.9%) males and 32 (71.1%) females while in group B 30 (66.7%) patients were females and 15 (32.3%) males. Mean body mass index of patients in group A was 22.84±5.47 kg/m2 while in group B mean BMI was 23.48±3.15 kg/m2. A significant short time of drainage was found in group A 5.36±1.24 days as compared to group B 7.96±1.84 days (p-value <0.05). At 1st postoperative day mean drain output in group A was 110.34±29.43 ml and in group B it was 130.48±45.27 ml. At 5th postoperative day drain output in group A was 58.38±30.42 ml and in group B it was 89.64±32.55 ml, a significant difference was found between both groups with p-value <0.05. In group A, 4 (8.89%) patients had seroma while in group B 7 (15.56%) patients had seroma, the difference was not statistically significant.

Conclusion: The use of tranexamic acid for prevention of postoperative seroma formation in patients undergoing ventral hernioplasty was effective with less interval of time for removal of drain.

Keywords: Drain output, Tranexamic acid, Ventral hernia, Seroma