Abstract

Background: Ineffective uterine muscle contraction after delivery is a major cause of excessive haemorrhage and may necessitate emergency hysterectomy. Published literature has determined the role of vitamin D deficiency in development of various maternal complications but its role in development of uterine atony is still a point to ponder and research.

Aim: To determine the correlation of vitamin D with uterine musculature contraction among pregnant women after delivery.

Study Design: Case control study.

Setting: Department of Obstetrics & Gynaecology, Sheikh Zayed Medical College/Hospital Rahim Yar Khan.

Duration of Study: 1st January 2020 to 30th June 2020.

Methods: A total of 100 subjects with uterine atony were taken as cases while 100 subjects with normal uterine tone were taken as controls according to selection criteria and taking informed consent. A blood sample of 5 ml was taken by vene-puncture using aseptic techniques after delivery. Blood sample was collected in serum vial and was sent to the laboratory for serum vitamin D levels the same day.

Results: In our study most of the women were from 20 to 35 years of age and 29.550± 2.25 years was the mean age in case group while 29.260± 2.46 years in control group and mean vitamin D level was 22.350±9.02 ng/ml in case group while 28.480±10.53 ng/ml in control group. Vitamin D deficiency was seen in 84 (84%) patients in Case group as compare to 57 (57%) patients in Control group (p=0.000, OR = 3.9).

Conclusion: In our study we observed that vitamin D is required for uterine musculature contraction and inadequate levels of vitamin D may lead to ineffective contraction of uterus after delivery resulting in postpartum haemorrhage.

Keywords: Vitamin D, uterine muscle contraction.