Abstract

Background: The bleeding which occurs without any demonstrable organic cause is known as dysfunctional uterine bleeding. Most commonly DUB presents at the extreme of ages as 20% in adolescence and 40% in over age of 40. A number of medications are available for the management of heavy menstrual blood loss. Antifibrinolytics like plasminogen activators inhibitors is well recognized treatment for heavy menstrual bleeding.

Aim: To establish exactly by research the effect of tranexamic acid in reducing the PBAC in patients of DUB.

Study design: Descriptive case series

Setting: Gynae & Obstetrics Department in Punjab Rangers Hospital, Lahore

Results: Out of 225 patients 135(60%) were found between 25-30 years and 90(40%) were aged between 31-35 years. The calculated Mean and Standard Deviation were 29.34±4.23.Comparison of PBAC score before and after administration of tranexamic acid shows 387.2±97.45 ml blood loss before treatment and 186.8±103.76 after treatment and the difference was recorded as 200.4±6.31 while we recorded 51.75% reduction in blood loss after treatment.

Conclusion: We concluded that a remarkable reduction in PBAC after treatment with tranexamic acid in patients of Dysfunctional Uterine Bleeding.

Keywords: Dysfunctional uterine bleeding, medical treatment, PBAC, tranexamic acid