Abstract

Aim: To determine the frequency of coagulopathy in patients of hypertensive disorders in pregnancy at tertiary care hospital.

Methods: The study was conducted at Department of Obstetrics and Gynaecology, Unit-II, Nishtar Hospital, Multan during 15th November 2015 to 15th May 2016. A purposive sample of 132 women with gestational hypertension/ preeclampsia/ eclampsia, parity 0-4, gravida 1-5, gestational age >20 weeks were included in the study. Patients having known cases of chronic hypertension, pre pregnancy bleeding disorder and amniotic fluid embolism were not included in the sample.

Results: Patients arriving in antenatal clinic, labour room at gynaecology department of Nishtar Hospital fulfilling the inclusion and exclusion criteria were enrolled for the study. Collected primary data was analyized and it was observed that different factors such as: age varied from 20 to 40 years with mean age:29.090±3.84 years, mean gestational age: 28.000±2.87 weeks, mean PT: 9.530±3.82 seconds, mean APTT: 33.401±5.33 seconds, mean INR: 1.105±0.24, mean platelets: 203.765±78.91X109/L and mean Serum Fibrinogen was turned out to be: 241.045±60.08 mg/dL. Majority of the women were with pregnancy induced hypertension: 68.2%, while women with preeclampsia were 19.7% and with eclampsia were observed to be: 12.1%. Also, Coagulopathy was observed in 12.1% of patients.

Concluded: Risk of coagulopathy increases with the development of eclampsia and as a result it will help to identify patients who may have chances of developing coagulopathy and these patients require immediate referral so as to reduce maternal and perinatal mortality and morbidity rates.

Keywords: Hypertensive disorders; Pregnancy; Coagulopathy.