Abstract

Background: Fibromyalgia is a common condition characterized by long-term, body pains mainly due to vitamin-D deficiency resulting in depression.

Aim: To assess the role of vitamin-D deficiency in the development of depression among fibromyalgia patients.

Study Design: Cross-sectional analysis.

Methodology: With a sample of 92 patients the present project was carried from January to July 2019 in the Dept. of Pharmacology, Allama Iqbal Hospital, Lahore following the Hospital’s Ethical Committee approval. Vitamin D and serotonin blood levels were done. Patients were treated with vitamin D with calcium at 1000mg daily dose. Results: Out 92 patients, 58(63%) were males and 34(37%) were females. In 87% fibromyalgia patients were over-weight and obese. Results indicated that that the mean serotonin levels were significantly higher in patients with normal vitamin D levels as compared to vitamin D deficient groups with p-value <0.001*

Conclusion: It was concluded that vitamin-D deficiency developed fibromyalgia and depression with low serotonin levels especially among females.

Keywords: Vitamin D, Fibromyalgia, Depression and Serotonin.