Background and objective: However Hyperhomocysteinemia is a hazard factor for cardiovascular disease; it isn't known whether it is related to hazards cardiac outcome in acute coronary syndrome. To determine the short term (28days) effects of either raised or normal homocysteine levels in the acute coronary syndrome patients.

Methodology: Present descriptive study was held at cardiology department of Liaquat University of Medical and health Science. Study duration was seven months from July 2017 to January 2018. Patients having acute coronary syndrome and either of gender were included. Blood sample was taken from each patient for Homocysteine level. Homocysteine level >15 μmol/L was defined as raised and its short term effects were noted among patients of acute coronary syndrome. Patients were followed during Hospital stay and through OPD for 28 days. Data was entered in the self-made proforma.

Results: Mean age of enrolled patients was 54.84+10.55 years. Males were commonest 72.5%. Homocysteine level >15mmol/I was in 57.50% patients. Short term effects as arrhythmias were 14.2% and re-infarction was in 4.2% patients, while mortality rate was 2.4%. Theses short term effects were significantly related to elevated Homocysteine level (>15 μmol/L) (p=0.058).

Conclusion: Raised homocysteine level was highly prevalent in acute coronary syndrome and it was markedly linked to short term effects including re-infarction, arrhythmias and mortality as compare to those having normal homocysteine level.