FATEMEH NAVAEI 1,2, MOHAMMAD ALI EBRAHIMZADEH3, EBRAHIM NASIRI FORMI4, AGHDAS EBADI JAMKHANEH5, MAJID SAEEDI6, FERESHTEH BEIGOM TALEBPOUR AMIRI7, SEYDE SEDIGHE YOUSEFI8*

The Effect of plantago major VAGINAL SUPP on Heavy Menstrual Bleeding Patients with Uterine Leiomyoma: A Double-blind Randomized Clinical Trial

FATEMEH NAVAEI 1,2, MOHAMMAD ALI EBRAHIMZADEH3, EBRAHIM NASIRI FORMI4, AGHDAS EBADI JAMKHANEH5, MAJID SAEEDI6, FERESHTEH BEIGOM TALEBPOUR AMIRI7, SEYDE SEDIGHE YOUSEFI8*



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ABSTRACT
Background: One major symptom associated with leiomyomas is heavy menstrual bleeding (HMB). This study
aimed to assess the effects of plantain leaf extract vaginal suppositories (p. major supp) on the control of HMB in
pMaettiehnotds sw: itIhn uat edroinueb llee i-obmlinydo mraan.d omized, clinical trial 60 women with uterine leiomyoma and HMB were randomly
assigned to the intervention/placebo groups by Stratified block randomization. The intervention group received p.
major vaginal supp and mefenamic acid capsule, whereas the control group received placebo vaginal supp and
mefenamic acid capsule every 8 hours in the first 3 days of menstruation for 3 menstruation cycles. The amount
and duration of bleeding were evaluated using the pictorial blood loss assessment chart (PBAC) and calendar,
rReesspuelcttsiv: eTlyh.e mean of PBAC decreased from 652.6±189 baseline to 175.6±139 in the intervention group and
Increased from 775.3± 192 to 825 ± 247 in control group in third month. A trend of improvement was significant in
the intervention group, and there was a significant difference between the groups. The mean of bleeding duration
sChoonwceluds iimopnr:o Pve. mmeanjot ri nv apgaitnieanl tssu opfp t hwee irnete ervffeencttiioven ginr oduepc rweiathsoinugt aP BsiAgnCi fisccaonrte dsi fifne rtehnec ien tbeervtweenetionn t hger otwupo; gdreosuppiste.
its effectiveness in decreasing the duration of menstrual bleeding in the intervention group, the effect was not
significant compared to the control group in patients who suffered from uterine leiomyoma (UL). Clinically,
however, the difference was significant; patients in the placebo group experienced more days of bleeding than the
intervention group. P. major vaginal supp could be suggested as a complementary treatment for controlling HMB
iKne pyawtioerndtss :s uPf.f emrianjgo rf rvoamg inUaLl, sbuupt pfu, lrethioemr sytoumdiae,s m aeren orerrqhuaigreiad,. Plantago major, Persian Medicine,


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