Qamar Sajad, Adnan Ali, Yasir Raheem Malik


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ABSTRACT
Aim: To govern the importance of rapid virological response in predicting adverse side effects in the in patients with chronic hepatitis C treated with sofosbuvir and ribavirin and to determine the importance of antiviral therapy.
Study Design: A Prospective cohort study.
Place and Duration: Gastroenterology Department of Services Hospital Lahore from March 2019 to March 2020.
Methodology: All the cases of chronic hepatitis C treated with sofosbuvir and ribavirin for 24 week were clinically evaluated. The treatment response was inveterate after four and twenty four weeks of treatment called Rapid Virological response (RVR) and also evaluated for End Treatment Response (ETR), respectively. Adverse reactions of treatment was observed every one month for a full 24-week treatment. The main features of the population were observed. A new inception or deteriorating of existing anemia is considered significant while fatigue, headache, coughing, insomnia and itching during treatment was also observed. RVR deficiency was confirmed by statistical dependence on side effects of treatment using SPSS version 20.0.
Results: 52% of 100 patients were women and 48% were men. The patient's age is 45.68 ± 10.71 years to 22 to 70 years old. RVR was 91% (91out of 100) while ETR was 95% (95 out of 100). The baseline anemia was noted in 38% of patients and there was no anemia among 62% of people. The 66% of patients were observed with new onset and worsening of anemia. Other side effects developed during therapy, headache (39%), fatigue (56%), insomnia (14%), itching (5%) and cough (23%). There was a statistically significant relationship with RVR deficiency and headache (p = 0.002), fatigue (p = 0.037), coughing. (p = 0.000) and insomnia (p = 0.021).
Conclusion: Response of patients with chronic hepatitis C to sofosbuvir and ribavirin is remarkable in the population of Pakistan. The deficiency of RVR after treatment for four weeks predicts the common adverse effects during entire 24 weeks of treatment.
Keywords: Sofosbuvir, hepatitis C, Ribavirin, rapid virological response, adverse reactions.


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