ABSTRACT

Aim: To examine the clinical presentation, complications and outcomes of paraphenylene diamine poisoning patients admitted to intensive care unit. Study Design: Retrospective/Observational Place and Duration of Study: Department of Medicine, Chandka Medical College Hospital, Larkana from 1st October 2019 to 31st March 2020. Methodology: One hundred and thirty patients of both genders presented with paraphenylene diamine poisoning were enrolled. Patients detailed demographics including, age, sex, clinical presentation and complete blood picture were recorded. Complications and outcomes were examined. Results: One hundred and sixteen (89.23%) were females while 14 (10.77%) were males. The mean age of patients was 24.52±6.48 years. Suicide was the most common reason of ingestion of paraphenylene diamine found in 92% cases. Cervico-facial edema was the commonest symptom found in 90% cases. Raised creatinine was most common complication found in 60 (46.15%) patients followed by sodium deficiency in 42 (32.31%) and potassium deficiency in 28 (21.54%) patients. 78(60%) patients were recovered, 45(34.61%) were died and 7(5.38%) were LAMA.

Conclusion: Females were high in number in paraphenylene diamine poisoning, suicidal was the commonest reason and Cervico-facial edema was the most common clinical presentation. Mortality rate was 35% while 60% patients were recovered.

Key words: Paraphenylene diamine (PPD) poisoning, clinical features, complication recovered mortality