ABSTRACT

Aim: To determine the frequency of acute hepatitis in cases of paraphenylenediamine (PPD) poisoning at tertiary care hospital.

Methods:This cross sectional study was conducted at Department of Medicine, Sahiwal Medical College, Sahiwal fromMarch 2019 to September 2019 over the period of 6 months.Total 163 patients following PPD intoxication taken within 24 hours having age 20-60 years either male or female were selected. Base line investigations were done for all selected patients and demographic profile of the patients were recorded in pre-designed proforma.5ml blood sample was taken for serum ALT and sent to laboratory for assessment of acute hepatitis.

Results: Total 163 patients with PPD intoxication were selected and acute hepatitis was studied.Mean age of the patients was 41.63 ± 11.69 years.Out of 163 patients, acute hepatitis was noted in 109 (67%) patients.Male patients were 63 (38.65%) and female patients were 100 (61.35%) and acute hepatitis was found in 44 (69.84%) male patients and 65 (65%) female patients.Association of acute hepatitis with gender was found statistically insignificant with p value 0.523.Among 69 (42.33%) patients, duration of PPD intoxication was 1-12 hours and in 94 (57.67%) was 13-24 hours.Acute hepatitis was noted in 46 (66.67%) patients of 1-12 hours group and in 63 (67.02%) patients of 13-24 hours group.But association between acute hepatitis and duration of PPD intoxication was statistically insignificant with p value 0.962.

Conclusion: Results of present study showed that most of the patients were female as compared to male patients with PPD poisoning.Higher rate of acute hepatitis was noted.No association of acute hepatitis with age, gender, duration of PPD poisoning and socioeconomic status.Most of the patients were married and middle pass.