Talha Laique, Rehana Kousar, Mohammad Majid Jehangir, Rabiya Saif , Ayesha Ahmad, Jahanzeb Malik

Life Saving New Modality In Advanced Cervical Carcinoma: Cisplatin Plus Radiation Therapy

Talha Laique, Rehana Kousar, Mohammad Majid Jehangir, Rabiya Saif , Ayesha Ahmad, Jahanzeb Malik



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ABSTRACT

 

Background: Cervical carcinoma is linked with morbidity and high death rate among females globally.

Aim: To determined the loco-regional control among advanced cervical carcinoma patients receiving concomitant chemo-radiation therapy.

Methodology: Following hospital’s ethical committee approval, all patients (n=113) received cisplatin (40mg/m2) with radiation-therapy in two phases. All patients were evaluated for treatment response. Chi-square and Fisher's exact test was applied as p-value ≤ 0.05 was considered significant by using SPSS software, version 20.

Results: In present study, age (mean ± SD) of the enrolled subjects (n=113) turned out to be 50.8 ± 10.2 years with range 30 to 65 years. There was a good response shown to treatment given by the patients. In our study, 61 (54.0%) patients showed complete response, while in 32 (28.3%) patients partial response rate was observed.

Conclusion: Treatment with concomitant chemo-radiation therapy showed good response (82.3%) in our enrolled patients. Hence, we concluded that CCRT treatment modality is more effective that radiation therapy alone in terms of response shown by the patients.

Keywords: Cervical carcinoma, Treatment Response and Concomitant Chemo-Radiation Therapy.



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