Size Discrepancy of Residual Tumor between Post Chemotherapy Sonography And On Post Excision Histopathology after Neo Adjuvant Chemotherapy (NAC) and its impact on 5 Years Disease Free Survival
Naseera Khanum, Waqas A Locum, Asma Riaz, Bushra Rehman, Khadija Nasir, Tabinda Naik, J Mohsin, A Pervaiz
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ABSTRACT
Aim: Size
discrepancy of residual tumor between post chemotherapy sonography and on post
excision histopathology after neo adjuvant chemotherapy (NAC) and its impact on
5 years disease free survival.
Methodology: The date was retrospectively reviewed between Jan 2012 to Dec 2012.
Total 88 patients were included. All patients received chemotherapy before
surgery. Both mastectomy and BCS were included. Ultrasound examination was done
before surgery and final H/P sizes were noted. Discrepancies lesser than 10mm
were ignored b/c of operator dependency and b/c both were different mode of
examinations.
Results: Out of
88 patients 22 (25%) showed zero discrepancy, 45 (51%) patients showed discrepancies
lesser than 10mm. 21(23%) patients showed more than 10mm discrepancy. Out of
these 21 patients, in 9 patients ultrasound showed lesser size and in 12
patients ultrasound showed larger size. Largest discrepancy was shown to be
100mm in which ultrasound showed no lesion (occult) however on final H/P it was
100mm. Second largest discrepancy was 48mm in which ultrasound showed 48mm
tumor size, however, final H/P showed no tumor (occult). All patients were
followed for 5 years. Total 30 patients out of 88 (34%) showed recurrence.
Conclusion: The ultrasound examination by large is a sensitive mode for determining
size of tumor after NAC as shown in our study.
Keywords: Neo
adjuvant chemotherapy, ultrasound, discrepancy
ABSTRACT
Aim: Size
discrepancy of residual tumor between post chemotherapy sonography and on post
excision histopathology after neo adjuvant chemotherapy (NAC) and its impact on
5 years disease free survival.
Methodology: The date was retrospectively reviewed between Jan 2012 to Dec 2012.
Total 88 patients were included. All patients received chemotherapy before
surgery. Both mastectomy and BCS were included. Ultrasound examination was done
before surgery and final H/P sizes were noted. Discrepancies lesser than 10mm
were ignored b/c of operator dependency and b/c both were different mode of
examinations.
Results: Out of
88 patients 22 (25%) showed zero discrepancy, 45 (51%) patients showed discrepancies
lesser than 10mm. 21(23%) patients showed more than 10mm discrepancy. Out of
these 21 patients, in 9 patients ultrasound showed lesser size and in 12
patients ultrasound showed larger size. Largest discrepancy was shown to be
100mm in which ultrasound showed no lesion (occult) however on final H/P it was
100mm. Second largest discrepancy was 48mm in which ultrasound showed 48mm
tumor size, however, final H/P showed no tumor (occult). All patients were
followed for 5 years. Total 30 patients out of 88 (34%) showed recurrence.
Conclusion: The ultrasound examination by large is a sensitive mode for determining
size of tumor after NAC as shown in our study.
Keywords: Neo
adjuvant chemotherapy, ultrasound, discrepancy