ABSTRACT

Background: Wound infection is a common complication after cesarean section. However, certain antibiotics, if given before closing wound, the Wound infection can be prevented. So we conducted this trial to determine the benefit of two antibiotics in prevention of post-cesarean wound infection.

Aim: To compare the efficacy with prophylaxis ceftriaxone versus ceftriaxone plus metronidazole in patients undergoing planned cesarean section.

Methods: This Randomized controlled trial (experimental study) was done at Department of Obstetrics and gynecology, Aziz Bhatti Shaheed Teaching Hospital, Gujrat for 6 months. The patients were recruited by applying non-probability consecutive sampling technique. The patients were divided randomly in 2 groups of equal number of cases. In group A, patients were given IV ceftriaxone as single dose of 1g before skin incision. In group B, patients were given IV ceftriaxone 500mg plus IV metronidazole 500mg before skin incision. Then patients underwent cesarean section under spinal anesthesia. Patients were followed-up for 10 days. If there was no sign of infection at wound site, then efficacy was labeled.

Results: In ceftriaxone group, average age of patients was 30.36±6.84 years and in combination group, patients had mean age of 29.10±6.95 years. All patients presented within 38-42 weeks of gestation. Efficacy was achieved in 84% cases with ceftriaxone while in 78% in combination group. Statistically there was no significant difference detected between both groups i.e. (p 0.279).

Conclusion: Thus, there is no difference in efficacy in both groups, so we can implement the use of ceftriaxone alone instead of combination with metronidazole.

Keywords: Wound infection, Lower segment cesarean section, Prophylaxis, Ceftriaxone, metronidazole.