ABSTRACT

Aim: To find the association of prolonged pre-labour rupture of membranes in infants at term with early-onset neonatal sepsis.

Study design:It is a descriptive case series study

Place study: Department of Gynecology and Obstetrics, Rahber Medical and Dental College and Pakistan Rangers Hospital, Lahore.

Methodology:A written informed consent was taken from all the patients who were included in the study. Study was continued for six months. 100 mothers were enrolled in the study. Non-probability convenience sampling technique was used.

Inclusion criteria:

 Mothers withrupture of membranes 24 hours before labor and

 Gestational age between 37 to 42 weeks.

Exclusion criteria: Mothers with following risk factors were excluded;

 Infants having any congenital anomaly and

 Mothers taking antibiotics prior to admission

Results: A total of 100 patients were enrolled in the study. Mothers were classed into different groups according to their ages. According to gravidity (G), mothers were divided into 4 groups. Mothers were divided in 4 groups on the basis of parity (para). Blood culture reports were retrieved. Staphylococcal aureus was detected in 25% of cases (25/100). Klebsiella and coagulase negative staphylococcus in 5% each. Acinobacter species and pseudomonas were detected in 3% of cases each. Enterococci were present in 2% of cases (2/100). Enterobacter species and streptococci were detected in 1% each.

Conclusion: Prolonged PROM leads to neonatal sepsis

Keywords: PPROM promneonatal sepsis chorioamnionits