Life Saving New Modality In Advanced Cervical Carcinoma: Cisplatin Plus Radiation Therapy
Talha Laique, Rehana Kousar, Mohammad Majid Jehangir, Rabiya Saif , Ayesha Ahmad, Jahanzeb Malik
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ABSTRACT
Background: Cervical carcinoma is linked with morbidity
and high death rate among females globally.
Aim: To determined the loco-regional control among
advanced cervical carcinoma patients receiving concomitant chemo-radiation
therapy.
Methodology: Following hospital’s ethical committee approval,
all patients (n=113) received cisplatin (40mg/m2) with radiation-therapy in two phases. All patients were
evaluated for treatment response. Chi-square and Fisher's exact test was
applied as p-value ≤ 0.05 was considered significant by using SPSS software,
version 20.
Results: In present study, age (mean ± SD) of the enrolled subjects (n=113) turned out to be 50.8 ±
10.2 years with range 30 to 65 years. There was a good response shown to
treatment given by the patients. In our study, 61 (54.0%) patients showed
complete response, while in 32 (28.3%) patients partial response rate was
observed.
Conclusion: Treatment with concomitant chemo-radiation
therapy showed good response (82.3%) in our enrolled patients. Hence, we
concluded that CCRT treatment modality is more effective that radiation therapy
alone in terms of response shown by the patients.
Keywords: Cervical carcinoma, Treatment Response and Concomitant
Chemo-Radiation Therapy.
ABSTRACT
Background: Cervical carcinoma is linked with morbidity
and high death rate among females globally.
Aim: To determined the loco-regional control among
advanced cervical carcinoma patients receiving concomitant chemo-radiation
therapy.
Methodology: Following hospital’s ethical committee approval,
all patients (n=113) received cisplatin (40mg/m2) with radiation-therapy in two phases. All patients were
evaluated for treatment response. Chi-square and Fisher's exact test was
applied as p-value ≤ 0.05 was considered significant by using SPSS software,
version 20.
Results: In present study, age (mean ± SD) of the enrolled subjects (n=113) turned out to be 50.8 ±
10.2 years with range 30 to 65 years. There was a good response shown to
treatment given by the patients. In our study, 61 (54.0%) patients showed
complete response, while in 32 (28.3%) patients partial response rate was
observed.
Conclusion: Treatment with concomitant chemo-radiation
therapy showed good response (82.3%) in our enrolled patients. Hence, we
concluded that CCRT treatment modality is more effective that radiation therapy
alone in terms of response shown by the patients.
Keywords: Cervical carcinoma, Treatment Response and Concomitant Chemo-Radiation Therapy.