Background

: Despite the high prevalence and large number of studies on chronic bacte rial prostatitis, no

effective treatment has been found for this disease.

Aim

: T o compare the therapeutic effect of ciprofloxacin and the combination of propolis and ciprofloxacin on

patients with chronic bacterial prostatitis.

Methods

: This study was per formed as a single blind randomized clinical trial. 190 men with chronic bacterial

prostatitis in Qom in 2018 2019 who met the inclusion criteria, formed the statistical population of this study and

the samples were selected by census of patients with bact erial prostatitis by the available method. The subjects

were randomly assigned to 2 groups receiving ciprofloxacin and a combination of ciprofloxacin and propolis.

Blood and urine sampling was performed at the beginning of the study and at the end of the 3 0 day treatment

period. Data analysis was performed using SPSS software version 16 and t he significance level was considered

to be less than 0.05.

Results:

The data obtained from WBC and ESR analysis of patients in both groups before and after the study di d

not show a significant difference. In the study of International Prostatic Symptoms Score, there was no significant

difference between the severity of symptoms before treatment in different parameters, but after studying the

severity of symptoms and thei r improvement showed a significant difference. In the first group, 45.7% but in the

propolis group, 63.5% improvement was achieved. Based on the pain measurement criteria, the severity of pelvic

pain in the two groups before the study was not significantly different, but after the study, the observed difference

between the two groups was significant. Based on the results, the rate of pain relief in the first group was 51%

and in the second group was 65.8%.

Conclusion:

Propolis as an anti inflammatory and im mune system booster, antimicrobial, antioxidant, anti tumor,

without any side effects can be used in the treatment of chronic infections and inflammation.

Keywords

Ciprofloxacin, Propolis, Chronic bacterial prostatitis.