Background: One major symptom associated with leiomyomas is heavy menstrual bleeding (HMB). This study

aimed to assess the effects of plantain leaf extract vaginal suppositories (p. major supp) on the control of HMB in

pMaettiehnotds sw: itIhn uat edroinueb llee i-obmlinydo mraan.d omized, clinical trial 60 women with uterine leiomyoma and HMB were randomly

assigned to the intervention/placebo groups by Stratified block randomization. The intervention group received p.

major vaginal supp and mefenamic acid capsule, whereas the control group received placebo vaginal supp and

mefenamic acid capsule every 8 hours in the first 3 days of menstruation for 3 menstruation cycles. The amount

and duration of bleeding were evaluated using the pictorial blood loss assessment chart (PBAC) and calendar,

rReesspuelcttsiv: eTlyh.e mean of PBAC decreased from 652.6±189 baseline to 175.6±139 in the intervention group and

Increased from 775.3± 192 to 825 ± 247 in control group in third month. A trend of improvement was significant in

the intervention group, and there was a significant difference between the groups. The mean of bleeding duration

sChoonwceluds iimopnr:o Pve. mmeanjot ri nv apgaitnieanl tssu opfp t hwee irnete ervffeencttiioven ginr oduepc rweiathsoinugt aP BsiAgnCi fisccaonrte dsi fifne rtehnec ien tbeervtweenetionn t hger otwupo; gdreosuppiste.

its effectiveness in decreasing the duration of menstrual bleeding in the intervention group, the effect was not

significant compared to the control group in patients who suffered from uterine leiomyoma (UL). Clinically,

however, the difference was significant; patients in the placebo group experienced more days of bleeding than the

intervention group. P. major vaginal supp could be suggested as a complementary treatment for controlling HMB

iKne pyawtioerndtss :s uPf.f emrianjgo rf rvoamg inUaLl, sbuupt pfu, lrethioemr sytoumdiae,s m aeren orerrqhuaigreiad,. Plantago major, Persian Medicine,