Evaluation of Therapeutic Effect of Eugenia caryophillats product on Mild and Moderate Depressed Patients; A Randomized, Double Blinded and Placebo Controlled Clinical Trial Study
Bita Sadeh, Assie Jokar, Mohammad Azadbakht, Jamal Shams, Mehran Zarghami, Ebrahim Nasiri
1635
ABSTRACTBackground: Depression is a serious disease in society today. Its approximate lifetime prevalence in some developed countries is high at about 21%. Some herbs have been used in traditional medicine for many years to treat many diseases including depression and anxiety. Clove is an important medicinal plant due to its extensive proven medicinal effects over the centuries.Aim: To investigate the mechanisms of antidepressant drugs in Persian medicine and to evaluate the therapeutic effect of adding clove products in patients receiving citalopram with mild to moderate depression.Methods: First, antidepressants were extracted from Traditional Persian medicine (TPM) books by library study and tabulated according to their mechanism. Then a clinical trial study was performed to evaluate the antidepressant properties of cloves. This study was performed on 60 patients with mild to moderate depression. In this way, patients' depression was first confirmed based on interviews, examinations and Beck questionnaire. They were then randomly divided into two groups of 30 people. In one group, clove product was prescribed with citalopram and the other group received placebo with citalopram. Patients were re-evaluated after 2, 4 and 6 weeks and patients completed the Beck questionnaire.Results: Our results showed a relative improvement at weeks 2 and 4, but no significant difference was observed with the placebo group. But there was a significant improvement and difference in the clove product group in the sixth week after the start of the study compared to the placebo group.Conclusion: Many herbal medicines have been mentioned in TPM books that had antidepressant properties. These types of herbal medicines remedies need further study to determine their beneficial properties in relieving depressive disorders. Clove was found to be effective in treating depression during this trial. Clove product can be effective as a drug in the treatment of mild to moderate depression.Keywords: Depression, Clove, Carnation, Citalopram, Traditional Persian medicine (TPM).
Background: Depression is a serious disease in society today. Its approximate lifetime prevalence in some developed countries is high at about 21%. Some herbs have been used in traditional medicine for many years to treat many diseases including depression and anxiety. Clove is an important medicinal plant due to its extensive proven medicinal effects over the centuries.
Aim: To investigate the mechanisms of antidepressant drugs in Persian medicine and to evaluate the therapeutic effect of adding clove products in patients receiving citalopram with mild to moderate depression.
Methods: First, antidepressants were extracted from Traditional Persian medicine (TPM) books by library study and tabulated according to their mechanism. Then a clinical trial study was performed to evaluate the antidepressant properties of cloves. This study was performed on 60 patients with mild to moderate depression. In this way, patients' depression was first confirmed based on interviews, examinations and Beck questionnaire. They were then randomly divided into two groups of 30 people. In one group, clove product was prescribed with citalopram and the other group received placebo with citalopram. Patients were re-evaluated after 2, 4 and 6 weeks and patients completed the Beck questionnaire.
Results: Our results showed a relative improvement at weeks 2 and 4, but no significant difference was observed with the placebo group. But there was a significant improvement and difference in the clove product group in the sixth week after the start of the study compared to the placebo group.
Conclusion: Many herbal medicines have been mentioned in TPM books that had antidepressant properties. These types of herbal medicines remedies need further study to determine their beneficial properties in relieving depressive disorders. Clove was found to be effective in treating depression during this trial. Clove product can be effective as a drug in the treatment of mild to moderate depression.
Keywords: Depression, Clove, Carnation, Citalopram, Traditional Persian medicine (TPM).