Breast cancer is cancer that forms in the cells of the breasts.Most women diagnosed with breast cancer are over the age of 50, but younger women can also get breast cancer. A total of 115 women patients with breast tumor (55 malignant and 60 benign) and 40 females as a control group. Epidemiology and risk factors were determined using questionnaire form. Different blood and immunological parameters were evaluated. Results indicated obvious relation between risk factor and breast cancer (BC), among these factors is the age; the most frequent age for breast cancer was that at age group (38- 47). The study showed, there was a marked increase in the total mean of WBC count, granulocytes, lymphocytes and monocytes in breast cancer and benign breast disease when compared with control group (P ˂ 0.05). There was a significant increase in the concentrations of all the immunological parameters (IL- 6, IL- 8, IFN- γ) and tumor marker CA15- 3, the oxidative stress (Adenosine Deaminase) activity, IgG, IgM, IgA, C3 and C4 in patients in comparison with the control group.

Key words: Prevalence, Risk factor, Cytokine, CA15.3, ADA activity, breast cancer