Papillary thyroid carcinoma (PTC) accounts roughly 75% cases of total thyroid malignant tumors. Purpose: To access the diagnostic accuracy of ultrasound in nodular papillary thyroid carcinoma. Study Design: Cross-sectional study. Methodology: Patients (n=153) having thyroid nodules were enrolled to conduct the present study at Department of Otorhinolarynogology Khyber Teaching Hospital, Peshawar-Pakistan for 6 months keeping confidence interval 95%,and 9% margin of error. Enrolled patients were informed and consent was taken. Statistical analysis: Mean ± SD for age whereas frequency and percentage were given for gender and type of nodules was given by SPSS version 20. Significant p-value was of ≤0.05. Results: The mean age of patients was 49 ± 2.13 years. Majority patients (74%) had multinodules while 26% patients had solitary nodules. Sensitivity of ultrasound as a diagnostic tool in our study was 75% whereas specificity was 92%. Conclusion: Thyroid ultrasound is a relatively an accurate modality for diagnosing Papillary thyroid carcinoma. Keywords: Ultrasonography, Papillary Thyroid Carcinoma and Imaging Modality