Background: Primary immunodeficiency diseases (PID) are a group of rare, chronic disorders in which part of the body’s complex immune system is either missing or functioning improperly.

Aim: To collectively assess the knowledge of health care providers about Primary immune deficiency diseases.

Methods: A cross-sectional study design was used with a 49-item questionnaire consisting of various close-ended questions on etiology, 26 clinical situations associated with PID and laboratory data presentation regarding PID patients was circulated to be filled by training doctors in various hospitals of Punjab. Responses collected and scores created with the percentage of correct responses employed as a knowledge indicator.

Results: A total of 103 training doctors participated in the study: 66 medical students (64.1%),18 house officers (17.5%), 11 medical officers (10.7%) and 8 post-graduate trainees (7.8%).The mean percentage of the correct responses on etiology expertise of primary immune deficiency was (73.4%) , knowledge regarding clinical symptoms in both adults and children was (66.51%) and (67.9%)respectively while lab analysis cognition was seen in (49.56%) of the respondents.

Conclusion: This study showed that there is insufficient knowledge among training doctors regarding etiology and presentation of primary immune deficiency diseases. Inceptive correction of education skills is the premier strategy by which long term adversity resulting from lack of knowledge can prevent adversities in patients of primary immune deficiency.

Keywords: Primary Immunodeficiency Diseases, Training Doctors and Knowledge