Aim: To compare the outcomes of misoprostol and oxytocin for labor induction in women with post-term pregnancy.

Study Design: Randomized controlled trial

Place & duration: Department of Obstetrics & Gynaecology, Muhammad College of Medicine (former Al Razi Medical College) Peshawar from 1stJanuary 2020 to 30thJune 2020.

Methodology: One hundred pregnant women with gestational age >38 weeks were included. Patient’s detailed demographics were recorded after taken informed consent. All the patients were equally divided into two groups. Each group contained 50 patients. Group 1 received two doses of 50ug misoprostol orally at 6 hours while group 2 received 5 units of oxytocin in 500ml RL. Maternal outcomes such as time duration from induction to delivery and mode of deliver were examined, fetal outcomes were also examined and compare between both groups.

Results: In group 1 mean age of patients was 26.24±4.78 years and in group 2 it was 27.12±3.62 years, no significant difference was observed with p-value >0.05. No significant difference was found regarding induction to delivery interval in both groups 1 and 2 (7.36±1.58 hours and 7.88±1.69 hours) p-value >0.05, no significant difference was observed regarding mode of delivery. No significant difference was observed between both groups regarding Apgar score at 5 minutes and NICU admission.

Conclusion: Misoprostol orally and oxytocin both are safe and effective for induction of labor in women with post-term pregnancy.

Keywords: Labor induction, Misoprostol, Oxytocin, Maternal Outcome, Neonatal outcomes