Objective: To determine the frequency of common bacteria with antibiotic sensitivity among patients with acute appendicitis. Study Design: Cross Sectional study Place and Duration of Study: Department of Surgery, District Headquarter Hospital and Mardan Medical Complex from 1st January 2019 to 31st July 2019 Methodology: All patients were subjected to appendectomy. Patients with antibiotic use in the last one week or those with diabetes were excluded from the study. Biopsy specimen was sent to the laboratory for culture to detect E Coli, Streptococci, Pseudomonas, Klebsiella and Enterococci. All the detected bacteria were tested against commonly used antibiotics. Results: The mean age was 30 (2.54) years with 113 (63%) male and 66 (37%) female patients. E coli was found in 122 (68%) patients, Streptococci in 48 (27%), Pseudomonas in 45 (25%), Klebsiella in 21 (12%), while 18 (10%) patients had Enterococci. The patients with E Coli, Klebsiella, and pseudomonas frequently responded well to most of the antibiotics like Ceftazidine, gentamicin, and ceftriaxone. Streptococci was most sensitive to ciprofloxacin, gentamicin, and Cefradine.

Conclusion: The most common bacteria in patients presenting with acute appendicitis was E Coli followed by Streptococci, Pseudomonas, Klebsiella, and Enterococci. A minority of these bacteria had developed resistance to the commonly used antibiotics like Amoxicillin, Ciprofloxacin, and Ceftriaxone.

Key words: Amoxicillin, Bacteriology, Broad spectrum, E. coli, Culture, Resistance, Sensitivity