A Correlation between Leptin and Thyroid Hormones in Population with Obesity
Meita Hendrianingtyas, Dwi Retnoningrum, Aryu Candra Kusumastuti, Satrio Adi Wicaksono, Sulistiyati Bayu Utami
1391
ABSTRACTBackground: Obesity has become a major problem in Southeast Asian countries, including Indonesia. Adipocyte cells produce leptin, which plays a role in regulating one's appetite and is associated with obesity. In obesity, chronic inflammation occurs, altering various hormonal activities throughout the body, including the activities of thyroid hormones. However, the correlation between leptin levels and thyroid hormone levels in obese population remains unclear.Aim: To determine the correlation between leptin levels and thyroid hormone levels in obese population.Method. This study involved 33 participants with obesity (BMI >27) at Diponegoro National Hospital, Semarang. Leptin levels were measured using enzyme-linked immunoassay (ELISA), while thyroid hormones (TSH, T3, FT3, T4 and FT4) were measured using immunology analyzer. Correlation analyses between variables were performed using Pearson and Spearman correlation test.Results: There was a significant positive correlation between leptin levels and TSH level (r=0.503; p=0.003). There were no correlations between leptin levels and levels of T3, FT3, T4 and FT4.Conclusion: Leptin levels might influence TSH levels, and both leptin and thyroid hormones might impact on theurapeutic approach in patients with obesity.Keywords: leptin, thyroid hormones, TSH, obesity
Background: Obesity has become a major problem in Southeast Asian countries, including Indonesia. Adipocyte cells produce leptin, which plays a role in regulating one's appetite and is associated with obesity. In obesity, chronic inflammation occurs, altering various hormonal activities throughout the body, including the activities of thyroid hormones. However, the correlation between leptin levels and thyroid hormone levels in obese population remains unclear.
Aim: To determine the correlation between leptin levels and thyroid hormone levels in obese population.
Method. This study involved 33 participants with obesity (BMI >27) at Diponegoro National Hospital, Semarang. Leptin levels were measured using enzyme-linked immunoassay (ELISA), while thyroid hormones (TSH, T3, FT3, T4 and FT4) were measured using immunology analyzer. Correlation analyses between variables were performed using Pearson and Spearman correlation test.
Results: There was a significant positive correlation between leptin levels and TSH level (r=0.503; p=0.003). There were no correlations between leptin levels and levels of T3, FT3, T4 and FT4.
Conclusion: Leptin levels might influence TSH levels, and both leptin and thyroid hormones might impact on theurapeutic approach in patients with obesity.
Keywords: leptin, thyroid hormones, TSH, obesity