The Effects of Alkaline Reduced Water Administration to the Fasting Blood Glucose Levels in Patients with Type 2 Diabetes Mellitus
Satrio Adi Wicaksono, Dina Hisan Nabyla, Sulistiyati Bayu Utami
1260
ABSTRACTBackground: Alkaline reduced water (ARW) is an electrolyzed water with pH>7. It showed an antioxidant and an antidiabetic benefit, but the results still vary.Aim: To investigate the effect of ARW to fasting blood glucose (FBG) and two-hours post prandial glucose (2hPPG) in Indonesian patients with type-2 diabetes mellitus (T2DM).Methods: This was a randomized double blind controlled trial performed in September 2017- September 2018. Thirty patients that had been diagnosed with T2DM in one hospital in Semarang and met the inclussion criteria were determined by consecutive sampling. Subjects were randomly divided into two groups: ARW group (pH 9) (n=15) and control group (mineral water, OMW) (pH 7) (n=15). Both were administered orally 1 liter per day for 12 days; FBG and 2hPPG were measured before and after 12 days treatment.Results: There were no differences in FBG and 2hPPG at pre-treatment, in 2hPPG at post-treatment, and in decrease beween pre-and post-treatment 2hPPG (Δ2hPPG) between ARW group and OMW group. At post-treatment, there was a lower FBG in ARW group compared to OMW group, although it was not significant (214.8±12.66 mg/dL vs 225.1±15.44 mg/dL, p=0.056). There was a wider decrease of FBG (ΔFBG) in ARW group compared to OMW group (19.4±1.68 mg/dL vs 14.3±3.64 mg/dL, p=0.000).Conclusion: ARW decreased FBG in patients with T2DM yet 2hPPG. These findings might have important implications for the management of T2DM.Keywords: alkaline reduced water, fasting blood glucose levels, type-2 diabetes mellitus, T2DM
Background: Alkaline reduced water (ARW) is an electrolyzed water with pH>7. It showed an antioxidant and an antidiabetic benefit, but the results still vary.
Aim: To investigate the effect of ARW to fasting blood glucose (FBG) and two-hours post prandial glucose (2hPPG) in Indonesian patients with type-2 diabetes mellitus (T2DM).
Methods: This was a randomized double blind controlled trial performed in September 2017- September 2018. Thirty patients that had been diagnosed with T2DM in one hospital in Semarang and met the inclussion criteria were determined by consecutive sampling. Subjects were randomly divided into two groups: ARW group (pH 9) (n=15) and control group (mineral water, OMW) (pH 7) (n=15). Both were administered orally 1 liter per day for 12 days; FBG and 2hPPG were measured before and after 12 days treatment.
Results: There were no differences in FBG and 2hPPG at pre-treatment, in 2hPPG at post-treatment, and in decrease beween pre-and post-treatment 2hPPG (Δ2hPPG) between ARW group and OMW group. At post-treatment, there was a lower FBG in ARW group compared to OMW group, although it was not significant (214.8±12.66 mg/dL vs 225.1±15.44 mg/dL, p=0.056). There was a wider decrease of FBG (ΔFBG) in ARW group compared to OMW group (19.4±1.68 mg/dL vs 14.3±3.64 mg/dL, p=0.000).
Conclusion: ARW decreased FBG in patients with T2DM yet 2hPPG. These findings might have important implications for the management of T2DM.
Keywords: alkaline reduced water, fasting blood glucose levels, type-2 diabetes mellitus, T2DM