Metabolic syndrome is closely related to several disturbances in lipid and lipoprotein metabolism. Apolipoprotein E (apoE) e4 genotype prevalence varies among patients with metabolic syndrome by region and within each country. Further exploration is warranted to better understand the substantial heterogeneity of these prevalence estimates. This review attempts to highlight the probability of apolipoprotein E gene polymorphism as a risk factor for metabolic syndrome and/or coronary heart disease complications. An extensive literature review related to apoE, metabolic syndrome, and coronary heart disease was performed to describe related issues. This knowledge is a fundamental prerequisite for a possible diagnostic application of these lipoproteins as biomarkers to predict adverse cardio-vascular disease and metabolic syndrome.

Keywords: Apolipoprotein, metabolic syndrome, cardiovascular