Aim: To determine the frequency of pre-extensively drug resistant TB, extensively drug resistant TB in patients with Multi-drug resistant TB

Study Design: Retrospective/Observational

Place and Duration: Abbottabad International hospital from September 2019 to Feb 2020

Methods: Total 220patients with both genders were enrolled in this study. Average age of patients was 18-60 years, with a BMI less than 30. Out of 220 patients, the ratio of males was 57% as compared to females. All patients were examined by using drug sensitivity testing.Pre-XDR showed high prevalence rate than that of XDR tuberculosis in patients with MDR.Patientsdetailed demographics were recorded after written consent.Data was analyzed by SPSS 24.0. Results:Out of 220 patients mostly patients 128(58.18%) were males while rest of the patients 91(41.82%) were females.The mean age of the patients was36.42±11.54 years with mean BMI 23.45±2.62.In multi-drug resistant TB, the occurrence of pre-XDR was in 75(34.09%) patients while in XDR the prevalence rate was 12(5.45%) in patients. All the patients of pre-XDR TBwere resistant to fluoroquinolone while patients of XDR TB were resisted to amikicin, kanamycin, capreomycin and fluoroquinolone.

Conclusion:Patients admitted with MDR TB had high prevalence of pre-extensively drug resistant TB as compared to extensively drug resistant TB.

Keywords: Tuberculosis, Multi-Drug Resistant, Pre-extensively drug resistant, Extensively drug Resistant