Background: One of usual problems is ureteral stones that needs care practice. Some pharmacological agents are used for treatment of ureteral stones. Alpha-blockers, i.e., tamsulosin, are extensively used for treatment of ureteral stones.

Aim: To compare the effects of Tamsulosin alone and in combination with Ketorolac on urinary symptoms in patients with ureteral stones.

Methods: This randomized clinical study was conducted between December 2016 and February 2016. A total number of 100 adult patients (>17 years of age) and with distal ureteric stones in size of 6–10 mm were assigned into 2 treatments including those intravenously received 0.4 mg Tamsulosin+30 mg Ketorolac (combination group) daily and other group was treated with 0.4mg tamsulosin daily. Urinary symptoms including dysuria and frequent urination were recorded. Pain changes were evaluated by Visual Analog Scale (VAS). Statistical analyses were conducted by Chi-square test.

Results: The results showed that VAS was significantly reduced in pateints that received combination treatment compared to those received Tamsulosin alone (P<0.05), but dysuria and frequent urination was not different among groups (P>0.05).

Conclusion: A combination of α-blockers and non-steroidal anti-inflammatory drugs can have better efficiency compared to α-blocker agent.

Keywords: Dysuria, Frequent urination, Ketorolac, Medical therapy, Tamsulosin