Hemorrhagic septicemia (HS) is the most important disease of livestock caused by Pasteurella multocida serotype B: 2 (Asian countries) and serotype E:2 (African countries). The outbreak of Pasteurella multocida world widely gave serious economic impact in South and Southeast Asia, Africa and India. Respiratory system plays the main role in the route of transmission of the HS disease where the Pasteurella multocida enters the respiratory tract of infected animals through inhalation and passes into the bloodstream thus producing clinical signs including rising of body temperature, respiratory pain, inflammation, nasal discharge and lethargic. HS disease occurrence in peracute cases typically characterized as sudden onset which leading to rapid death of the infected animal. Diagnosis of HS disease was mainly based on the clinical sign and symptom, post mortem findings which polymerase chain reaction (PCR) frequently has been used for rapid, sensitive and specific detection of Pasteurella multocida. HS disease was usually treated with a wide range of antibiotics such as cephalosporins, florfenicol, tetracyclines, and fluoroquinolone. However, long term usage of the antibiotics resulting in multi-drug resistant against Pasteurella multocida. Thus, several studies on the development of a vaccine for HS disease was been done and still ongoing nowadays in preventing and control HS disease outbreak

Keywords: Pasteurella multocida; hemorrhagic septicemia; Diagnosis; Treatment; Antibiotic resistance