Immunological and molecular detection of Tumor necrosis factor-α (TNF-α) in Iraqi Women with Polycystic Ovarian Syndrome
Zainab Ali Hlail, Khalil Ismail Abd-Mohammed, Ahmed Sahib Abd-Ulamir, Mohammed Odah Salman
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ABSTRACTPolycystic ovary syndrome (PCOS) is the most common endocrinopathy among adult women in the developed world and is characterized by anovulation, androgen excess (primarily ovarian, but also adrenal in origin) and the appearance of polycystic ovaries on ultrasound. Diagnostic criteria are expert-based and debated as they do not incorporate known metabolic abnormalities related to aberrant insulin action, such as glucose intolerance, diabetes, and dyslipidemia that affect many women with the syndrome. Symptoms that are most troublesome to patients include hirsutism, obesity, infertility and menstrual disorders. The level of TNF-α increase significantly in PCOS than control groups. The SNP polymorphisms in the TNF-α gene have been associated with altered TNF-α secretion and are linked with PCOS and pregnancy problems. TNF-α genetic polymorphisms might be a risk factor for PCOS.Keyword: polycystic ovarian syndrome, tumor necrosis factor- alpha, single nucleotide polymorphism
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among adult women in the developed world and is characterized by anovulation, androgen excess (primarily ovarian, but also adrenal in origin) and the appearance of polycystic ovaries on ultrasound. Diagnostic criteria are expert-based and debated as they do not incorporate known metabolic abnormalities related to aberrant insulin action, such as glucose intolerance, diabetes, and dyslipidemia that affect many women with the syndrome. Symptoms that are most troublesome to patients include hirsutism, obesity, infertility and menstrual disorders. The level of TNF-α increase significantly in PCOS than control groups. The SNP polymorphisms in the TNF-α gene have been associated with altered TNF-α secretion and are linked with PCOS and pregnancy problems. TNF-α genetic polymorphisms might be a risk factor for PCOS.
Keyword: polycystic ovarian syndrome, tumor necrosis factor- alpha, single nucleotide polymorphism