Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease described by expanded mortality to a great extent owing to cardiovascular sickness. osteoprotegerin (OPG) is a recently distinguished glycoprotein, having a place with the tumor necrosis factor receptor superfamily, initially found as the inhibitor of bone resorption. Aim: To explore the relationship of the level of serum osteoprotegerin (OPG) level with the finding of asymptomatic coronary artery disease in the patient with rheumatoid arthritis (RA). Methods: The examination included 25 rheumatoid patients with CAD aided design (the positive outcomes on practice ECG stretch test) and other 26 rheumatoid patients without CAD aided design (negative outcomes on practice ECG push test and affirmed using coronary angiography). What's more, 30 age and sex coordinated typical control subjects were examined. Serum OPG was estimated utilizing Elisa test.

Results: This work showed that levels of serum OPG have been significant higher levels in rheumatoid patients without and with CAD than in controls (P < 0.012) also OPG was positively correlated with age, BMI, and negatively with duration of disease in patients with and without CAD. Conclusion: Osteoprotegerin is the medically meaningful particle autonomously connected with the nearness of coronary artery disease and might be a decent pointer of damage of the atherosclerotic vascular and macro angiopathy of the rheumatoid patients. Thus, estimation of serum OPG justifies advance examination as the basic test to enhance early the CAD diagnosis of the rheumatoid patients.

Key word: Osteoprotegerin , coronary artery disease, rheumatoid arthritis