Frequency of Factor V Leiden and Prothrombin G20210A Mutations in Sudanese Patients with Deep Vein Thrombosis in Khartoum Hospitals
Ayman HAlfeel, Ezeldine K. Abdalhabib, Abdullah AMobarki, Hassan A Hamali, Ibrahim K Ibrahim, Salah E GElzaki
1091
ABSTRACTBackground: Factor V Leiden (FVL) and prothrombin (PT) G20210A mutations play a crucial role in the development of deep vein thrombosis (DVT).Aim: To determine the frequency of factor V Leiden and PT G20210A polymorphisms in Sudanese patients with DVT and the associated risks.Methods: The current study was a hospital-based case-control survey, a total of 233 Sudanese subjects were enrolled within two groups: a patient group of 126 admitted with DVT and 107 age/ gender-matched healthy control group.Results: Possible risk factors for DVT were found as a family history of thrombosis, hypertension, diabetes, smocking habitat, cardiac disease, and pregnancy. Heterozygous mutations of FVL was detected in one case (0.8%), and none of the studied subjects had PT G20210A mutation.Conclusion: The current study suggests the presence of FVL and PT G20210A among patients with DVT. Further studies should be conducted to determine the prevalence of FVL and PTG 20210A mutations in a larger cohort.Keywords: deep vein thrombosis, factor V Leiden, prothrombin G20210A
Background: Factor V Leiden (FVL) and prothrombin (PT) G20210A mutations play a crucial role in the development of deep vein thrombosis (DVT).
Aim: To determine the frequency of factor V Leiden and PT G20210A polymorphisms in Sudanese patients with DVT and the associated risks.
Methods: The current study was a hospital-based case-control survey, a total of 233 Sudanese subjects were enrolled within two groups: a patient group of 126 admitted with DVT and 107 age/ gender-matched healthy control group.
Results: Possible risk factors for DVT were found as a family history of thrombosis, hypertension, diabetes, smocking habitat, cardiac disease, and pregnancy. Heterozygous mutations of FVL was detected in one case (0.8%), and none of the studied subjects had PT G20210A mutation.
Conclusion: The current study suggests the presence of FVL and PT G20210A among patients with DVT. Further studies should be conducted to determine the prevalence of FVL and PTG 20210A mutations in a larger cohort.
Keywords: deep vein thrombosis, factor V Leiden, prothrombin G20210A