Non-polio Enteroviruss Isolation in children with acute Flaccid Paralysis in Iraq
Nadia Aziz Nasir, Yusra H. Khalaf, Muhi K. Al-Janabi, Faisal G. Alhamdani, Ahmed A. Ali, Khalil I A. Mohammed
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ABSTRACT
Aim: This study is an
overview of NPEV investigated during AFP surveillance programs
for the period 2010–2017 in Iraq.
Methods: Stool
samples from 4296 AFP cases and 2933 healthy
contacts among children less than 15 years of age were
processed for virus isolation as a part of AFP surveillance for the Global
Polio Eradication Program in Iraq at National Polio Laboratory. NPEV detection
was performed by virus isolation on cell culture according to WHO
recommendations.
Results: The NPEV
isolation rate was 14% of
total AFP cases and 14.5% of healthy contacts. The infection rate was higher in males than
females with a male/female ratio of 1.5:1. The highest NPEV infection rate was
observed among the children aged 1-2 years and decrease significantly with
increasing age. Residual weakness after 60 days from paralysis onset was reported
in 26% and death in 1.5% of AFP cases
with positive NPEV isolates.
Conclusion: The NPEV circulation is common in our
environment and may play a role in causing AFP cases especially for younger age
groups, NPEV could be isolated from healthy persons and from persons whose
clinical findings do not resemble poliomyelitis.
Keywords:
Non-polio, enterovirus, acute flaccid paralysis
ABSTRACT
Aim: This study is an
overview of NPEV investigated during AFP surveillance programs
for the period 2010–2017 in Iraq.
Methods: Stool
samples from 4296 AFP cases and 2933 healthy
contacts among children less than 15 years of age were
processed for virus isolation as a part of AFP surveillance for the Global
Polio Eradication Program in Iraq at National Polio Laboratory. NPEV detection
was performed by virus isolation on cell culture according to WHO
recommendations.
Results: The NPEV
isolation rate was 14% of
total AFP cases and 14.5% of healthy contacts. The infection rate was higher in males than
females with a male/female ratio of 1.5:1. The highest NPEV infection rate was
observed among the children aged 1-2 years and decrease significantly with
increasing age. Residual weakness after 60 days from paralysis onset was reported
in 26% and death in 1.5% of AFP cases
with positive NPEV isolates.
Conclusion: The NPEV circulation is common in our
environment and may play a role in causing AFP cases especially for younger age
groups, NPEV could be isolated from healthy persons and from persons whose
clinical findings do not resemble poliomyelitis.
Keywords:
Non-polio, enterovirus, acute flaccid paralysis