Impact of Osteoprotegerin on Atherosclerotic Vascular Disorders in Iraqi Patients with Rheumatoid Arthritis
Zainab A.Razak Al-Sharifi, Haider Abd Jabbar Al-Ammar, Wafa Mansor Merza
952
ABSTRACT
Background: Rheumatoid arthritis
(RA) is a chronic inflammatory disease described by expanded mortality to a
great extent owing to cardiovascular sickness. osteoprotegerin (OPG) is a
recently distinguished glycoprotein, having a place with the tumor necrosis
factor receptor superfamily, initially found as the inhibitor of bone
resorption.
Aim: To explore the
relationship of the level of serum osteoprotegerin (OPG) level with the finding
of asymptomatic coronary artery disease in the patient with rheumatoid
arthritis (RA).
Methods:
The
examination included 25 rheumatoid patients with CAD aided design (the positive
outcomes on practice ECG stretch test) and other 26 rheumatoid patients without
CAD aided design (negative outcomes on practice ECG push test and affirmed using
coronary angiography). What's more, 30 age and sex coordinated typical control
subjects were examined. Serum OPG was estimated utilizing Elisa test.
Results:
This
work showed that levels of serum OPG have been significant higher levels in
rheumatoid patients without and with CAD than in controls (P < 0.012) also
OPG was positively correlated with age, BMI, and negatively with duration of
disease in patients with and without CAD.
Conclusion:
Osteoprotegerin
is the medically meaningful particle autonomously connected with the nearness
of coronary artery disease and might be a decent pointer of damage of the
atherosclerotic vascular and macro angiopathy of the rheumatoid patients. Thus,
estimation of serum OPG justifies advance examination as the basic test to
enhance early the CAD diagnosis of the rheumatoid patients.
Key
word: Osteoprotegerin
, coronary artery disease, rheumatoid arthritis
ABSTRACT
Background: Rheumatoid arthritis
(RA) is a chronic inflammatory disease described by expanded mortality to a
great extent owing to cardiovascular sickness. osteoprotegerin (OPG) is a
recently distinguished glycoprotein, having a place with the tumor necrosis
factor receptor superfamily, initially found as the inhibitor of bone
resorption.
Aim: To explore the
relationship of the level of serum osteoprotegerin (OPG) level with the finding
of asymptomatic coronary artery disease in the patient with rheumatoid
arthritis (RA).
Methods:
The
examination included 25 rheumatoid patients with CAD aided design (the positive
outcomes on practice ECG stretch test) and other 26 rheumatoid patients without
CAD aided design (negative outcomes on practice ECG push test and affirmed using
coronary angiography). What's more, 30 age and sex coordinated typical control
subjects were examined. Serum OPG was estimated utilizing Elisa test.
Results:
This
work showed that levels of serum OPG have been significant higher levels in
rheumatoid patients without and with CAD than in controls (P < 0.012) also
OPG was positively correlated with age, BMI, and negatively with duration of
disease in patients with and without CAD.
Conclusion:
Osteoprotegerin
is the medically meaningful particle autonomously connected with the nearness
of coronary artery disease and might be a decent pointer of damage of the
atherosclerotic vascular and macro angiopathy of the rheumatoid patients. Thus,
estimation of serum OPG justifies advance examination as the basic test to
enhance early the CAD diagnosis of the rheumatoid patients.
Key
word: Osteoprotegerin
, coronary artery disease, rheumatoid arthritis