Assessment of association between Duffy blood group phenotypes and susceptibility to develop preeclampsia and its severity
Alireza Rezvan, Mohammad Ali Torabi, Ehsan Taherifard, Nasrin Asadi, Alireza Ahmadkhani, Erfan Taherifard
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ABSTRACT
Aim: To
investigate the relationship between Duffy blood group and prevalence and
severity of preeclampsia in pregnant women referred to Shiraz University of
Medical Science affiliated hospitals.
Methods: This cross-sectional
was conducted in the Hafez and Zeinabiyyeh hospitals. The study population
consists of 53 preeclamptic women and 53 age-matched pregnant women without preeclampsia.
Diagnosis of preeclampsia was conducted based on the American College of
Obstetricians and Gynecologists (ACOG) criteria and preeclamptic women were
divided to 2 subsets of preeclampsia with mild features and preeclampsia with
severe ones.
Results:The results of current
study showed no significant differences in frequency of different phenotypes of
this blood group between the normotensive and preeclamptic patients (p-value=
0.094). Similarly, there was not any significant differences in prevalence of
each type of Duffy phenotypes in two subsets of the preeclampsia (p-value=
0.831).
Conclusion: Day by day, the
underlying pathologic pathways of formerly idiopathic diseases are being
discovered. Genetic codes have been shown to highly affect these pathways, triggering
a cascade that ends with the disease entity. However, our article does not
support a significant association between different positive phenotypes of DARC
and susceptibility to preeclampsia, these studies should be encouraged in order
to delineate the underlying biologic pathways and their disruption in
pathologic conditions.
Keywords: Duffy Blood-Group
System; DARC protein, human [Supplementary Concept]; Pre-Eclampsia
ABSTRACT
Aim: To
investigate the relationship between Duffy blood group and prevalence and
severity of preeclampsia in pregnant women referred to Shiraz University of
Medical Science affiliated hospitals.
Methods: This cross-sectional
was conducted in the Hafez and Zeinabiyyeh hospitals. The study population
consists of 53 preeclamptic women and 53 age-matched pregnant women without preeclampsia.
Diagnosis of preeclampsia was conducted based on the American College of
Obstetricians and Gynecologists (ACOG) criteria and preeclamptic women were
divided to 2 subsets of preeclampsia with mild features and preeclampsia with
severe ones.
Results:The results of current
study showed no significant differences in frequency of different phenotypes of
this blood group between the normotensive and preeclamptic patients (p-value=
0.094). Similarly, there was not any significant differences in prevalence of
each type of Duffy phenotypes in two subsets of the preeclampsia (p-value=
0.831).
Conclusion: Day by day, the
underlying pathologic pathways of formerly idiopathic diseases are being
discovered. Genetic codes have been shown to highly affect these pathways, triggering
a cascade that ends with the disease entity. However, our article does not
support a significant association between different positive phenotypes of DARC
and susceptibility to preeclampsia, these studies should be encouraged in order
to delineate the underlying biologic pathways and their disruption in
pathologic conditions.
Keywords: Duffy Blood-Group
System; DARC protein, human [Supplementary Concept]; Pre-Eclampsia