Ghanyia Jasim Shanyoor, Rawaa Abdul-Ameer Abdul-Jabbar, Ekhlass N. Ali,


860



ABSTRACT

 

Background: Allergic diseases affect a large group of population and the common types were asthma, rhinitis, and urticaria and newly found that IL-33 playing an important role in the pathogenicity of allergic diseases.

Aim: To evaluate the levels of IL-33 in adult patients has real allergic diseases (asthma, rhinitis, and urticaria) through detection of both positive assays of total and specific IgE of allergic diseases.

Methods: The total and specific immunoglobulin E (IgE) and IL-33 were determined in the serum of three types of allergic patients and healthy controls.

Results: There were highly significantly higher concentrations of IgE and IL-33 in the serum of patients with allergic diseases. Serum IL-33 and total IgE concentration are clearly statistically highly significant increases in three groups of patients (Rhinitis, Asthma, Urticaria) compared with healthy control (p< 0.001). No significant correlation between IL-33 levels and total IgE in four groups.

Conclusion: Our results show a significantly higher concentration in serum level IL-33 of patients with three types of allergic diseases (asthma, rhinitis, and urticaria).

Keywords: interleukin 33, allergic diseases, specific IgE. 



Copyright © Pakistan Journal of Medical & Health Sciences 2024. All rights reserved!