The role of Interleukin 33 in patients with Allergic Diseases who has a positive result of total and specific IgE
Ghanyia Jasim Shanyoor, Rawaa Abdul-Ameer Abdul-Jabbar, Ekhlass N. Ali,
860
ABSTRACT
Background: Allergic
diseases affect a large group of population and the common types were asthma,
rhinitis, and urticaria and newly found that IL-33 playing an important role in
the pathogenicity of allergic diseases.
Aim: To
evaluate the levels of IL-33 in adult patients has real allergic diseases
(asthma, rhinitis, and urticaria) through detection of both positive assays of
total and specific IgE of allergic diseases.
Methods: The
total and specific immunoglobulin E (IgE) and IL-33 were determined in the
serum of three types of allergic patients and healthy controls.
Results: There were
highly significantly higher concentrations of IgE and IL-33 in the serum of
patients with allergic diseases. Serum IL-33 and total IgE concentration are
clearly statistically highly significant increases in three groups of patients
(Rhinitis, Asthma, Urticaria) compared with healthy control (p< 0.001). No
significant correlation between IL-33 levels and total IgE in four groups.
Conclusion: Our
results show a significantly higher concentration in serum level IL-33 of
patients with three types of allergic diseases (asthma, rhinitis, and
urticaria).
Keywords: interleukin 33, allergic diseases, specific
IgE.
ABSTRACT
Background: Allergic
diseases affect a large group of population and the common types were asthma,
rhinitis, and urticaria and newly found that IL-33 playing an important role in
the pathogenicity of allergic diseases.
Aim: To
evaluate the levels of IL-33 in adult patients has real allergic diseases
(asthma, rhinitis, and urticaria) through detection of both positive assays of
total and specific IgE of allergic diseases.
Methods: The
total and specific immunoglobulin E (IgE) and IL-33 were determined in the
serum of three types of allergic patients and healthy controls.
Results: There were
highly significantly higher concentrations of IgE and IL-33 in the serum of
patients with allergic diseases. Serum IL-33 and total IgE concentration are
clearly statistically highly significant increases in three groups of patients
(Rhinitis, Asthma, Urticaria) compared with healthy control (p< 0.001). No
significant correlation between IL-33 levels and total IgE in four groups.
Conclusion: Our
results show a significantly higher concentration in serum level IL-33 of
patients with three types of allergic diseases (asthma, rhinitis, and
urticaria).
Keywords: interleukin 33, allergic diseases, specific
IgE.