Comparison of Sensitivity and Specificity of Aspartate Aminotransferase to Platelet Index (APRI) and FIB-4 with Transient Elastography: Fibro Scan in Chronic Hepatitis C Virus Infected Patients
Hakim Ali Abro, Asma Hameed, Mehwish Ejaz,, Hamid Khalil
750
ABSTRACT
Aim: To compared readily available non-invasive fibrosis indexes
with fibro scan for the fibrosis staging and predicting its progression in
Pakistani population.
Study Design: Retrospective cross-sectional study
Place and Duration of
Study: Department of Medicine, Chandka Medical
College Hospital, Larkana from 1st July 2019 to 31st
December 2019.
Methodology: One thousand four hundred and sixty four hepatitis C virus
(HCV) infected patients were got complete blood count, liver function tests,
enzyme-linked immunosorbent assay, polymerase chain reaction and fibro scan
done to perfectly diagnose ongoing hepatitis C infection. In order to
differentiate HCV fibrosis progression, we compared the effectiveness of readily
available aspartate aminotransferase (AST) to Platelet Index (APRI) and FIB-4
with fibro scan.
Results: Readily available serum indexes AST to Platelet Index and
FIB-4 were able to stage liver fibrosis in advanced stages of fibrosis (F4
especially) with correlation coefficient indexes 0.462, and 0.131 with
considerable specificities and sensitivities. For APRI >1.5, it did
predicted F4 stage with sensitivity of 87.6% and specificity of 74.8%. For
Fib-4> 3.25, it did predicted F4 stage with sensitivity of 72.3% and
specificity of 53.2%.
Conclusion: Readily available and cheap serum indexes, AST to Platelet
Index (APRI) and FIB-4 accurately predicted distinguished between cirrhotic and
non-cirrhotic stages in HCV infected patients in comparison to the costly and
rarely available Fibro scan score.
Key words: Hepatitis C, Blood Platelets, Fibro-scan score
ABSTRACT
Aim: To compared readily available non-invasive fibrosis indexes
with fibro scan for the fibrosis staging and predicting its progression in
Pakistani population.
Study Design: Retrospective cross-sectional study
Place and Duration of
Study: Department of Medicine, Chandka Medical
College Hospital, Larkana from 1st July 2019 to 31st
December 2019.
Methodology: One thousand four hundred and sixty four hepatitis C virus
(HCV) infected patients were got complete blood count, liver function tests,
enzyme-linked immunosorbent assay, polymerase chain reaction and fibro scan
done to perfectly diagnose ongoing hepatitis C infection. In order to
differentiate HCV fibrosis progression, we compared the effectiveness of readily
available aspartate aminotransferase (AST) to Platelet Index (APRI) and FIB-4
with fibro scan.
Results: Readily available serum indexes AST to Platelet Index and
FIB-4 were able to stage liver fibrosis in advanced stages of fibrosis (F4
especially) with correlation coefficient indexes 0.462, and 0.131 with
considerable specificities and sensitivities. For APRI >1.5, it did
predicted F4 stage with sensitivity of 87.6% and specificity of 74.8%. For
Fib-4> 3.25, it did predicted F4 stage with sensitivity of 72.3% and
specificity of 53.2%.
Conclusion: Readily available and cheap serum indexes, AST to Platelet
Index (APRI) and FIB-4 accurately predicted distinguished between cirrhotic and
non-cirrhotic stages in HCV infected patients in comparison to the costly and
rarely available Fibro scan score.
Key words: Hepatitis C, Blood Platelets, Fibro-scan score